Abstract
A series of benzoxathiin SERAMs with bicyclic amine side chains was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue.
MeSH terms
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Animals
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Bridged Bicyclo Compounds / chemistry*
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Bridged Bicyclo Compounds / pharmacology
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Female
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Kinetics
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Ligands*
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Models, Molecular
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Molecular Conformation
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Receptors, Estrogen / metabolism*
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Selective Estrogen Receptor Modulators / chemistry
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Selective Estrogen Receptor Modulators / metabolism*
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Selective Estrogen Receptor Modulators / pharmacology
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Structure-Activity Relationship
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Uterus / drug effects
Substances
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Bridged Bicyclo Compounds
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Ligands
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Receptors, Estrogen
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Selective Estrogen Receptor Modulators